Bemidji State University
BS in Environmental Studies, BA in English
Iowa State University
PhD in Biochemistry
Mayo Clinic
Postdoctoral work
Teaching
Genetics
Immunology
Cell Biology
Hematology
Advanced Projects
Research Interests
My research interests center around a category of cellular proteins called Rho-family GTPases. These GTPases participate in events that control cell movement and shape. Besides controlling cellular migration, Rho GTPases frequently act as signaling nodes within cells, and they participate in a wide variety of cellular events through their interactions with a series of upstream and downstream effector proteins. In particular, guanine nucleotide exchange factors (GEFs) play a critical role in events that stimulate the signaling function of GTPases.
Recent Work
Florke, R. R., Young, G. T., and Hamann, M. J. (2017) Unraveling a model of TCL/RhoJ allosterism using TC10 reverse chimeras. Small GTPases (Accepted)
Ackermann, K. L., Florke, R. R., Reyes, S. S., Tader, B. R., and Hamann, M. J. (2016) TCL/RhoJ plasma membrane localization and nucleotide exchange is coordinately regulated by amino acids within the N terminus and a distal loop region. J. Biol. Chem.291, 23604–23617
Ham, H., Guerrier, S., Kim, J., Schoon, R.A., Anderson, E.L., Hamann, M.J., Lou, Z., and Billadeau, D.D. (2013). Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J. Immunol.190, 3661–3669.
Anderson, E.L., and Hamann, M.J. (2012). Detection of Rho GEF and GAP activity through a sensitive split luciferase assay system. Biochem. J.441, 869–879.
